Professor Scott Schaus, collaborated With BU Biology Professor Ulla Hansen on research into chemical compounds that could help treat liver cancer. Professor Schaus provided the resources to synthesize and screen compounds to determine how effective these compounds could be in reducing a protein, called transcription factor LSF. LSF appears to play a role in the growth of liver.

This research was highlighted in a BU Today article in April 2012.

Congratulations to Professor John Porco, Professor Aaron Beeler and their colleague Mathieu Achard on their excellent paper Synthesis of Azaphilone-Based Chemical Libraries in ACS Combinatorial Science in February, 2012.

Congratulations to Professor Scott Schaus and colleagues at the Boston University School of Medicine (BUSM) on their paper that was highlighted in Sciencedaily.

The paper was published in the Journal of Virlogy, their research identified a novel compound that inhibits viruses from replicating. This could lead to the development of highly targeted compounds to block the replication of poxviruses, such as the emerging infectious disease, Monkeypox.

Congratulations to Joe Tucker and Professor Corey Stephenson on their excellent paper Tandem Visible Light-Mediated Radical Cyclization–Divinylcyclopropane Rearrangement to Tricyclic Pyrrolidinones in Organic Letters in September 2011.

Congratulations to John Goodell, formerly of the CMLD-BU now at the University of Pittsburgh, and Jennifer Poole formerly of the CMLD-KU now at Yale University, Professor Aaron Beeler, Professor Jeffrey Aubé, and Professor John A. Porco, Jr on their excellent paper Synthesis and Reactivity of Bicyclo[3.2.1]octanoid-Derived Cyclopropanes in J. Org. Chem. ASAP in October 2011.

Congratulations to Brad Balthaser, Meghan Maloney, Professor Aaron Beeler, Professor John Porco, & Professor John Snyder on their excellent paper Remodelling of the Natural Product Fumagillol Employing a Reaction Discovery Approach in Natural Chemistry in October 2011.

Congratulations to Suwei Dong, Professor John Porco, and their collaborators Professor Richard Johnson and Kate Cahill from UNH, and John Beutler from NCI, on their excellent paper Microwave-Based Reaction Screening: Tandem Retro-Diels–Alder/Diels–Alder Cycloadditions of o-Quinol Dimers in The Journal of Organic Chemistry in September 2011.

Congratulations to Matthew Medeiros, Professors Scott E. Schaus, and John Porco, on their excellent paper A Cycloisomerization/ Friedel–Crafts Alkylation Strategy for the Synthesis of Pyrano[3,4-b]indoles in Organic Letters in July 2011.

Congratulations to our speakers, sponsors, vendors, and all the participants and organizers who made the 2011 Symposium a great success. View the list of speakers.

Congratulations to our colleague Professor Corey Stephenson, who won the 2010 Boehringer Ingelheim New Investigator Award in Organic Chemistry. Read BU's Chemistry announcement.

Congratulations to Professors John Porco, Aaron Beeler, and our colleagues at The Department of Infectology,and The Department of Lead Identification at The Scripps Research Institute–Scripps Florida, Jupiter, Florida, on their excellent paper A Time-Resolved Fluorescence–Resonance Energy Transfer Assay for Identifying Inhibitors of Hepatitis C Virus Core Dimerization in Mary Ann Liebert, Inc., in February 2010.

Read the press release from The Scripps Research Institute.

Congratulations to John Goodell, Bo Leng, and Tracy Snyder on their excellent paper Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones in Thieme on eJournal in April 2010.

Congratulations to Matthew R. Medeiros, Radha S. Narayan, and Nolan T. McDougal on their excellent paper Skeletal Diversity via Cationic Rearrangements of Substituted Dihydropyrans in Organic Letters ASAP on June 15 2010.

Congratulations to Jean-Charles Marie (formerly of the Porco Group), Yuan Xiong (of the Porco Group), former CMLD-BU members Adam Yeager and Geanna Min and our colleagues at Columbia University on their excellent paper Enantioselective Synthesis of 3,4-Chromanediones via Asymmetric Rearrangement of 3-Allyloxyflavones published in J. Org. Chem., Article ASAP on June 7 2010.

Alice McKenney joined the CMLD in April 2010 as the new CMLD Center Administrator. Ms. McKenney previously worked at Massachusetts General Hospital as a Grants Coordinator in the Center for Human Genetic Research. She received her B.A. in Communication from the University of Massachusetts/Amherst and her Ed.M. in Higher Education Administration from Boston University. The CMLD welcomes Ms. McKenney to the CMLD, and congratulates her on her new role.

Congratulations to Hidenori Kinoshita, Oscar J. Ingham, Winnie W. Ong, Aaron B. Beeler and John A. Porco, Jr. on their excellent paper "Tandem Processes Identified from Reaction Screening: Nucleophilic Addition to Aryl N-Phosphinylimines Employing La(III)-TFAA Activation" published in J. Am. Chem. Soc. ASAP on April 15, 2010.

Congratulations to John Goodell and our collaborators at the KU CMLD (Jen Treece and Jeff Aubé) on their paper, Reaction Discovery Using Microfluidic-Based Multidimensional Screening of Polycyclic Iminium Ethers, in J. Org. Chem on February 17, 2010.

Bo Liang and Srinivas Kalidindi's paper "Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles" is accepted for publication by the American Chemical Society on Jan 5th 2010.

Professor Thomas Gilmore, will receive the 2009 Metcalf Cup and Price. Professor Gilmore is the Director of the CMLD's Chemical Library Consortium, and Professor of Biology at Boston University.
Teaching and engaging in research at BU since 1987, Professor Gilmore's primary area of research focuses on the molecular biology of cancer, especially as it relates to lymphoma. More recently, he has been conducting research on the evolutionary origins of the immune response in simple marine organisms, such as sea anemones and coral. He has written approximately 100 scientific articles, and his research has been recognized by awards from the American Cancer Society. Professor Gilmore will receive the award during the main Commencement ceremony on May 17. Read the full announcement and listen to Professor Gilmore talk about his work.

Professor John Porco spoke at the New York Academy of Sciences on February 26th 2009.
Professor Porco talks about his work as director of CMLD-BU. And about how CMLD-BU combines a high-throughput, combinatorial, parallel approach to the investigation of chemical reactions with intensive study of the reaction mechanisms and intermediates that result in interesting new compounds. Other speakers included R. Kiplin Guy of St. Jude Children's Research Hospital and Daniel Erlanson of Carmot Therapeutics, Inc.

"Schaus Group Develops New Asymmetric Route To a-Amino Acid Esters"

"ArtusLabs Collaborates with Boston University to Create Three Dimensional Structures"

"Boston University's Ninth Annual Symposium on Chemical Synthesis : Advances and Applications"
June 27, 2008, Boston, Massachusetts
Speakers : Craig W. Lindsley (Associate Professor of Pharmacology and Chemistry, Vanderbilt University Medical School), David R. Liu (Professor of Chemistry and Chemical Biology, Harvard University), Peter Seeberger (Professor, ETH, Zürich), and Laura L. Kiessling (Professor and MacArthur Foundation Fellow, University of Wisconsin, Madison)
Hosted by the Center for Chemical Methodology and Library Development at Boston University

"2008 Visions in Chemistry - Symposium"
May 15, 2008 - Raritan Valley Community College, North Branch, New Jersey
"New Approaches to the Discovery of Novel Chemical Reactions and Chemotypes"
Speaker : Prof. John A. Porco, Jr.

"MedChem Europe - 4th Annual MedChem Europe Conference and Exhibition"
February 19-20, 2008 - Stockholm, Sweden
"New Approaches to the Discovery of Novel Chemical Reactions and Chemotypes"
Speaker : Aaron Beeler.

"GVK BIO-Wyeth Symposium - New Directions in Organic Synthesis"
October 5, 2007 - Hyderabad International Convention Center, Hyderabad, India
Director John A. Porco will give a talk on research conducted at the CMLD-BU as part of a symposium marking the inauguration of the GVK BIO-Wyeth Hyderabad Chemistry Center.

"CMLD-BU Field Day"
September 28, 2007 - The CMLD-BU hosted its first Field Day in Newton, MA
Researchers and staff from the CMLD and its affiliated research groups descended on Auburndale Cove Park in Newton for food and games. The day's events included a barbeque lunch, music, plenty silliness and horseplay. Lab members and couples sparred on the inflatable joust for bragging rights or to settle disputes; teams competed in a Funtathalon for medals; and horseshoes, bocce, frisbee, kickball and volleyball filled the afternoon. Special thanks go to Administrative Coordinator Sarah Coenen for all her hard work in putting the day together.

"2007 Program Meeting for the Centers of Excellence in Chemical Methodologies and Library Development"
The Center for Chemical Methodology and Library Development at the Broad Institute of Harvard and MIT will host the 2007 CMLD Program Meeting on July 23-24 in Cambridge, MA.

"EUROCOMBI4 : First International Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials"
July 15-18, 2007, Firenze, Italy
"New Approaches to the Discovery of Novel Chemical Reactions and Chemotypes"
Speaker : John A. Porco, Jr.

"Boston University's Eighth Annual Symposium on Chemical Synthesis : Advances and Applications"
June 22, 2007, Boston, Massachusetts
Speakers :Anna K. Mapp, Associate Professor of Chemistry & Medicinal Chemistry, University of Michigan, "Small Molecule Control of Gene Activation"; Klavs F. Jensen, Professor of Chemical Engineering, Massachusetts Institute of Technology, "Microsystems for Flow Synthesis – Status and Opportunities"; Paul R. Hanson, Professor of Chemistry, The University of Kansas, "Sultam Libraries: New Methods and Facilitated Protocols"; K. Barry Sharpless, Professor of Chemistry, The Scripps Research Institute, "Recent Advances in Click Chemistry"
Hosted by the Center for Chemical Methodolgy and Library Development at Boston University.

"24th Conference on Combinatorial Chemistry"
April 24, 2007, Osaka University Convention Center, Osaka, Japan
"New Approaches to the Discovery of Novel Chemical Reactions and Chemotypes"
Speaker : John A. Porco, Jr.

"Pfizer, Inc. Sponsors Research Collaboration between CMLD-BU and MIT"
In October 2006, a collaboration between the CMLD-BU and the laboratory of Klavs Jensen at the Massachusetts Institute of Technology received funding through Pfizer, Inc. The award supports efforts by the CMLD-BU and the Jensen lab to develop a microfluidics reactor platform for the exploration of new chemical reactions.

"CMLD-BU Professor receives Ignition Award"
Virus Chaser : Creating New Chemistry to Fight Disease
Professor John Snyder has received an Ignition Award from the Boston University Office of Technology Development. This one-year award will support research exploring flaviviruses with collaborator Eric Barklis of the Oregon Health and Science University.

"CMLD-BU Class of 2006"
The CMLD-BU congratulates its graduating seniors! Valerie Curtis, Stephanie Chichetti, Winnie Ong, and Geanna Min completed their Baccalaureate degrees at Boston University this May, and the CMLD-BU is grateful for their tremendous contributions to our research. Thank you and best of luck!

"AstraZeneca Sponsors CMLD-BU Research"
The CMLD-BU is proud to announce that it has received funding from AstraZeneca R&D Boston to sponsor a post doctoral researcher to develop novel chemistries. In keeping with their long-standing commitment to academic research, AstraZeneca has chosen to support the basic research activities at the CMLD-BU through a two-year collaborative arrangement that includes research opportunities in AstraZeneca R&D Boston facilities as well as at Boston University.