| The Medicinal Chemistry and
Core Synthesis Facility at Boston University (MCCSF-BU) is
a new component of the CMLD-BU tasked with optimizing the biological
properties of screening hits identified from CMLD-BU chemical
libraries. The facility will also conduct lead
optimization of other candidate molecules identified in biological
studies. Applying modern, technology-enabled medicinal chemistry
techniques, the MCCSF will optimize potency, selectivity,
and physical properties of hit compounds in order to provide
biological collaborators with high-quality
molecular probes. These probes will be used to probe enzyme function,
to modulate cellular function, and to screen in phenotypic
assays.
Compounds developed in the context of these hit-to-probe medicinal chemistry programs will be deposited in the
National Institutes of Health (NIH) Molecular Libraries Small Molecule Repository, thereby continuing to enhance this high-throughput screening deck. |
