| In September 2005, the Center
for Chemical Methodology and Library Development at Boston
University
(CMLD-BU) received a three-year grant from the
National Institutes of Health (NIH) for Generation of Stereochemically
and Structurally Complex Chemical Libraries. Our goal is to develop five distinct libraries
utilizing novel chemistries. These libraries will be included in the
National Institutes of Health Molecular Repository. Target
pilot libraries include unique structures that do not overlap in chemical space with molecules
currently in the PubChem database.
The Molecular Libraries and Imaging Initiative is a component of the New Pathways to Discovery,
which seeks to enable the rapid transformation of new scientific knowledge into tangible
benefits for public health. While high-throughput screening (HTS) of small-molecule libraries is widespread
in the pharmaceutical industry, the goal of the
Molecular Libraries (ML) Roadmap Initiative is to facilitate the use of HTS and chemical
libraries within the academic community. It is anticipated that the ML initiative will produce research tools
(including novel small-molecule modulators of cellular function and phenotypic assays)
to facilitate studies of biology and physiology. |
