| The Center for Chemical Methodology
and Library Development at Boston University (
CMLD-BU ) is a new center funded by the National
Institute of General Medical Sciences ( NIGMS ) focused
on the discovery of new methodologies to produce novel chemical
libraries of unprecedented complexity for biological screening.
The goal of the CMLD-BU is to explore and expand the diversity
of small-molecule libraries by creating general, useful protocols
for stereocontrolled synthesis. This process will involve the creation
of novel chemical libraries that uniquely probe three-dimensional space by employing stereochemical
and positional variation within the molecular framework as diversity
elements for library design. A major objective of the CMLD-BU
is also to provide information and chemistry protocols to the public
on parallel and chemical library synthesis. The CMLD-BU has also
organized the Chemical Library Consortium (CLC) to provide members of the biology community with access to its chemical
libraries. The CLC will ultimately enable the demonstration of the
quality of any given library through the identification of molecules that can be utilized
as tools to investigate cellular processes.
CMLD centers of excellence supported by NIGMS
have also been established at the University
of Pittsburgh ,
The Broad Institute of MIT and Harvard and the
University of Kansas. | 
